About this ingredient
Alpha Lipoic Acid (ALA), also known as thioctic acid, is a naturally occurring sulfur-containing compound involved in mitochondrial energy metabolism. It functions as a cofactor for important enzyme complexes involved in cellular energy production and has antioxidant properties. PubChem lists alpha-lipoic acid with the molecular formula C₈H₁₄O₂S₂ and molecular weight 206.3 g/mol.
ALA is widely used in nutritional supplements because of its role in antioxidant systems and cellular metabolism. It has been researched for oxidative stress, metabolic health and neurological applications.
One of the most extensively studied applications is diabetic peripheral neuropathy. Research has produced mixed results, although several systematic reviews and meta-analyses have reported improvements in certain neuropathy symptoms such as burning, numbness and tingling. A 2026 meta-analysis found potential benefits for several neuropathy symptom measures, while effects on long-term glycemic control and nerve-conduction measures remained inconclusive.
ALA should not be presented as a treatment or cure for diabetes. NCCIH reports that available evidence does not establish a benefit for controlling blood sugar, preventing diabetic macular edema, or improving diabetic kidney function.