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L Arginine

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Deep dive

About L-Arginine

Everything you need to know about this ingredient — sourced from our editorial team and the brands we work with.

About this ingredient

L-Arginine is a naturally occurring amino acid found in protein-containing foods and produced by the human body. It is classified as a conditionally essential amino acid, meaning that under certain physiological conditions the body's demand may exceed its ability to produce enough.

L-Arginine is particularly important because it participates in the body's nitric oxide pathway. Nitric oxide helps regulate blood-vessel dilation and blood flow. Arginine is also used by the body for protein synthesis and serves as a precursor for creatine production.

L-Arginine is commonly included in sports nutrition, pre-workout, amino-acid, circulation and general wellness formulations. However, research on supplemental arginine for improving athletic performance has generally produced limited or conflicting results. NIH's Office of Dietary Supplements reports little evidence that arginine supplementation substantially improves strength, endurance or recovery in healthy athletes.

L-Arginine is different from L-Citrulline, although the two ingredients are closely connected metabolically. The body can convert citrulline into arginine, while arginine can subsequently contribute to nitric oxide production.

Health benefits

  • ✓🩸 Supports nitric-oxide metabolism
  • ✓❤️ Supports healthy blood-flow research
  • ✓⚡ Supports amino-acid metabolism
  • ✓💪 Supports sports-nutrition formulations
  • ✓🏃 Supports exercise-performance research
  • ✓🧬 Supports protein synthesis
  • ✓🔋 Provides a precursor for creatine production
  • ✓🧠 Supports general nutritional amino-acid intake
  • ✓🔬 Supports research into vascular and metabolic pathways
  • ✓🌿 Provides a well-characterized nutritional ingredient

Common uses

  1. 1💊 L-Arginine capsules
  2. 2🥄 L-Arginine powder
  3. 3💊 L-Arginine tablets
  4. 4🏋️ Pre-workout formulations
  5. 5🏃 Sports-nutrition products
  6. 6🩸 Nitric-oxide support formulas
  7. 7❤️ Circulation-focused nutritional products
  8. 8💪 Amino-acid blends
  9. 9⚡ Performance and workout formulations
  10. 10🧬 Creatine-support nutritional formulations
  11. 11🔬 Amino-acid research
Got questions?

Frequently asked questions

What is L-Arginine?

L-Arginine is a naturally occurring amino acid involved in protein metabolism, creatine production and nitric oxide synthesis.

What does L-Arginine do in the body?

L-Arginine serves as a substrate for nitric oxide production and is also used for protein synthesis and creatine production.

Is L-Arginine an essential amino acid?

Arginine is generally considered conditionally essential because the body can synthesize it, but requirements can increase under certain physiological conditions.

What is L-Arginine commonly used for?

It is commonly found in sports nutrition, pre-workout, amino-acid and nitric-oxide-focused supplement formulations.

Does L-Arginine increase nitric oxide?

L-Arginine is a substrate used by nitric oxide synthase to produce nitric oxide. However, the effects of oral supplementation can vary between individuals and situations.

Is L-Arginine the same as L-Citrulline?

No. They are different amino acids, but they are metabolically connected. The body converts much of its citrulline into arginine.

Does L-Arginine improve exercise performance?

Current evidence is limited and conflicting. NIH reports little evidence that arginine supplementation significantly improves strength, endurance or exercise recovery in healthy individuals.

What foods contain L-Arginine?

L-Arginine occurs naturally in protein-rich foods including meat, poultry, fish, eggs, dairy products, legumes and nuts.

What are the possible side effects?

Higher supplemental amounts may cause gastrointestinal discomfort, diarrhea or nausea and may slightly lower blood pressure.

What is the chemical formula of L-Arginine?

L-Arginine has the molecular formula C₆H₁₄N₄O₂ and a molecular weight of approximately 174.20 g/mol.
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